Randomized Controlled Trials

In critically ill patients with septic shock, does hydrocortisone compared with placebo, reduce 90 day mortality?

No difference in mortality but significantly reduced ICU LOS, MV days, delay to resolution of shock and blood transfusions

In adult patients with non-traumatic out-of-hospital cardiac arrest, does a supraglottic airway device compared with tracheal intubation as the initial advanced airway management strategy, improve functional neurological outcome?

In adult patients with early septic shock, does peripheral perfusion-targeted resuscitation, compared to lactate level-targeted resuscitation, improve all cause mortality at 28 days?

In patients with acute myocardial infarction complicated by cardiogenic shock and evidence of multi-vessel disease on early diagnostic angiography, does immediate multi-vessel percutaneous coronary intervention (PCI) compared to culprit lesion …

In patients who are 6-24 hours post acute stroke, and have a mismatch between clinical deficit and infarct, does thrombectomy plus standard medical care, compared to standard medical care alone, …

In patients with proximal internal carotid (ICA) or middle cerebral artery (MCA) occlusion with likely salvageable ischaemic brain tissue, does thrombectomy, at 6-16 hours post ischaemic stroke, in addition to …

In patients with severe ARDS, does the early initiation of Extracorporeal Membrane Oxygenation (ECMO), compared to standard care, improve mortality at day 60?

In patients that survive with a good neurological outcome following out-of-hospital cardiac arrest, does 48 hours vs. 24 hours of therapeutic hypothermia, improve memory, attention & executive functions at 6 …

In patients with septic shock and severe acute kidney injury, does early vs. delayed renal replacement therapy improve 90 day mortality?

Is bag-mask ventilation noninferior to endotracheal intubation for initial airway management during advanced resuscitation of patients with out-of-hospital cardiac arrest?

In adult patients with out-of-hospital cardiac arrest (OOHCA), does the administration of epinephrine compared to placebo improve survival?

In adults suffering out-of-hospital non-traumatic cardiac arrest, does a strategy of airway management initially with laryngeal tube (LT) compared to endotracheal intubation (ETI) improve survival at 72 hours?

In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?

In high-risk patients undergoing angiography, does the administration of bicarbonate and/or acetylcysteine, compared with placebo, prevent major adverse events and acute kidney injury?

In adult patients undergoing major elective abdominal surgery, does a restrictive fluid regimen compared with a liberal fluid regimen reduce complications and improved disability-free survival?

In delirium free critically ill adult patients receiving sedation, does the addition of nocturnal low dose dexmedetomidine prevent delirium and improve sleep?

In critically ill patients does the administration of balanced crystalloids compared with saline, reduce a 30 day composite outcome of death, new renal replacement therapy or persistent renal dysfunction?

In ICU patients at risk of gastrointestinal (GI) bleeding does the use of prophylactic proton-pump inhibitor (PPI) compared to placebo reduce mortality at 90 days?

In high-risk patients receiving contrast medium, does prophylactic hydration with normal saline compared to no prophylaxis impact the rate of contrast-induced nephropathy?

ICU, RRTexcluded. Non-hydration non-inferior. Hydration more $$ & A/E (heart failure)

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In patients with moderate to severe acute respiratory distress syndrome (ARDS) does use of a lung recruitment maneuver associated with positive end-expiratory pressure (PEEP) titration according to the best respiratory-system …

In patients with refractory vasodilatory shock does the addition of angiotensin II improve blood pressure compared with standard vasopressor therapy?

Sig inc BP - ? clin sig. Not sig mort improvement (not powered mort, LOS, RRT)

In patients undergoing cardiac surgery with left ventricular dysfunction, does levosimendan compared to placebo reduce mortality?

In fluid responsive spontaneously breathing critically unwell patients undergoing resuscitation, does the collapsibility of the inferior vena cava (cIVC), as determined by point of care ultrasound (POCUS), when compared to …

Too many confounders (not RND, NICOM not std CO monitor)

In ventilated patients with sepsis, does a sedation strategy with dexmedetomidine compared with no dexmedetomidine improve mortality and number of ventilator-free days?