?
POLAR
2018 Trauma
? ICUs
510 patients
Clinical Question
In patients with severe blunt traumatic brain injury (TBI) does early and sustained cooling compared with standard care improve neurological outcomes at 6 months?
Critical Appraisal
Critique
Not blinded at the bedside, but outcome assessors blinded
A high proportion of patients randomised to hypothermia did not reach target temperature.
- Population
- Traumatic Brain Injury
- Population Details
- Severe TBI
- Intervention Arms
-
Hypothermia
33°C for 3 to 7 days - Control Arms
-
Avoid fevers
- Primary Outcome
- Survival with favourable neurology
- Secondary Outcomes
- No difference in mortality , No difference in neurological outcome , More bradycardia , More ventilator days , More pneumonia
- P Value
- 0.94
Outcome Results
Not recorded