EOLIA
2018 Respiratory
64 ICUs
249 patients
Clinical Question
In patients with severe ARDS, does the early initiation of Extracorporeal
Membrane Oxygenation (ECMO), compared to standard care, improve mortality
at day 60?
Critical Appraisal
Weaknesses
Implausible power calculation
Critique
Cross over to ECMO occurred in 35/125 (28%) of control patients
- Population
- ARDS
- Population Details
- MV < 7 days, Disease refractory to standard optimisation
- Intervention Arms
-
VV ECMO
- Control Arms
-
Standard Care
VV ECMO if SpO2 < 80% 6hrs - Primary Outcome
- 60 day mortality
- Secondary Outcomes
- Increase bleeding events , Increase thrombocytopenia
- P Value
- 0.09
Outcome Results
Not recorded
Primary location: France
Landmark trial