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SUP-ICU

2018 Acid Suppression
? ICUs
3298 patients

Clinical Question

In ICU patients at risk of gastrointestinal (GI) bleeding does the use of prophylactic proton-pump inhibitor (PPI) compared to placebo reduce mortality at 90 days?

Critical Appraisal

Critique

Composite secondary outcome

Population
Adult ICU Patients
Population Details
at least 1 risk factor for GI bleeding
Intervention Arms

40mg Pantoprazole IV daily
40mg Pantoprazole IV daily

Control Arms

Placebo

Primary Outcome
90 day mortality
Secondary Outcomes
Less clinically important bleeds
P Value
0.7

Outcome Results

Not recorded

Primary location: Europe ANZICS Landmark trial