ADRENAL

2018 Sepsis
? ICUs
? patients

Hydrocortisone 200 mg/day as a continuous infusion for 7 days or discharge from ICU

Clinical Question

In critically ill patients with septic shock, does hydrocortisone compared
with placebo, reduce 90 day mortality?

Critical Appraisal

Key findings

No difference in mortality but significantly reduced ICU LOS, MV days, delay to resolution of shock and blood transfusions

Critique

Underreporting of clinically relevant adverse effects

Population
Sepsis
Population Details
Not recorded
Intervention Arms

Hydrocortisone 200 mg/day as a continuous infusion for 7 days
Hydrocortisone 200 mg/day as a continuous infusion for 7 days

Control Arms

Placebo

Primary Outcome
90 day mortality
Secondary Outcomes
No difference in mortality , Hastened the reversal of shock , Decreased ICU LOS , Less mechanically ventilated days , Less blood transfusions
P Value
Not recorded

Outcome Results

Not recorded