#N/A
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
Evidence Library
Randomized Controlled Trials
#N/A
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
Do patients with severe diffuse traumatic brain injury and intracranial hypertension that was refractory to first-tier therapies who undergo bifrontotemporoparietal decompressive craniectomy have improved outcomes?
Mort sim. Dec ICP,ICU LOS, more unfavourable o/c (GCS 3-8, ICP > 20 15min)
- Population
- Traumatic Brain Injury
- Intervention
- Decompressive Craniectomy
- Control
- Standard Care
- Primary Outcome
- Extended Glasgow Outcome Score
Does bolus high dose frusemide (2.5x daily dose) reduced mortality in decompensated heart failure patients over low dose or infusion
- Population
- Not recorded
- Intervention
- Frusemide
- Control
- Not recorded
- Primary Outcome
- Not recorded
In critically ill adult patients, does late supplemental parenteral nutrition (PN), compared with early PN reduce the duration of dependency on intensive care?
Early PN > inc new infections, dur MV, hosp LOS, total healthcare cost
- Population
- Adult ICU Patients
- Intervention
- Late parenteral nutrition
- Control
- Early parenteral nutrition
- Primary Outcome
- ICU length of stay
In paediatric patients with severe febrile illnesses, in a resource limited setting, do fluid boluses with albumin vs. saline vs. no fluid boluses affect mortality?
Bolus fluids increase mortality at 28d, 90d (N/S & Alb) - NNH 30. Poor external validity, rural setting with limited resources, mostly children with malaria.
- Population
- Sepsis
- Intervention
- Albumin or saline bolus, 20-40ml/kg
- Control
- No bolus
- Primary Outcome
- Not recorded
In patients with cardiac arrest does adrenaline, compared to placebo, improve survival to hospital discharge?
Only 534 of 5000 recruited. Mult svcs w/d. Increase ROSC, no improvement d/c or neuro
- Population
- Cardiac Arrest
- Intervention
- Adrenaline 1mg every 3 minutes
- Control
- Placebo
- Primary Outcome
- Survival to hospital discharge
Loading...
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
Does nutritional support guided by measurements of resting energy expenditure (REE), compared with a weight-based regimen, improve survival in critically ill patients
Poor study design. Results not valid. Inc MV & ICU LOS but red mortality!?
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
In patients with moderate-severe ARDS does the early use of a neuromuscular blocking agent improve mortality?
Dec adjusted mortality & less barotrauma, PTX. Lower gen mortality > power
- Population
- ARDS
- Intervention
- Early cisatracurium infusion
- Control
- Placebo
- Primary Outcome
- Adjusted 90 day mortality
Loading...
- Population
- Sepsis
- Intervention
- Steroids
- Control
- Not recorded
- Primary Outcome
- Not recorded
In trauma patients with or at risk of significant haemorrhage, does the early administration of a short course of tranexamic acid (TXA) affect the mortality, incidence of occlusive events and …
Small ARR 28d mort. No reduction PRBC transfused, vasc occlusion, surg intervention
- Population
- Trauma Patients
- Intervention
- TXA
- Control
- Placebo
- Primary Outcome
- Death in hospital within 4 weeks
In mechanically ventilated patients without acute lung injury or acute respiratory distress (ALI/ARDS), does lower tidal volume ventilation at 6 ml/kg (Vt-low), compared to conventional tidal volume ventilation at 10 …
Low Vt > dec plasma IL-6. No diff BAL cytokine levels. Stopped early (more ALI in hi Vt)
- Population
- Adult ICU Patients
- Intervention
- Low volumes
- Control
- High volumes
- Primary Outcome
- Not recorded
#N/A
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
Pilot study. Using transpulmonary pressures to titrate PEEP.
- Population
- ARDS
- Intervention
- Transpulmonary Pressure
- Control
- ARDSnet protocol
- Primary Outcome
- Improvement in oxygenation
#N/A
- Population
- Sepsis
- Intervention
- target lactate clearance
- Control
- target ScvO2 > 70%
- Primary Outcome
- Not recorded
Loading...
dIVC useful predict FR in G3/4 Fisher SAH, low CI, MV 8ml/kg, sed & paralysed
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
In adult patients with suspected bacterial infections, does procalcitonin-guided antibiotic care compared to usual care reduce patient exposure to antibiotics without increasing mortality?
- Population
- Adult ICU Patients
- Intervention
- Procalcitonin-based antibiotic care
- Control
- Clinical decision
- Primary Outcome
- Days of antibiotic exposure
Comparison of Dopamine and Norepinephrine in the Treatment of Shock
No overall mortality difference. Cardiogenic shock had a worse outcome with dopamine.
- Population
- Shock
- Intervention
- Dopamine
- Control
- Noradrenaline
- Primary Outcome
- 28 day mortality
#N/A
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
Is extracorporeal membrane oxygenation (ECMO) a safe, efficacious and cost-effective treatment compared with conventional ventilation for the management of severe adult respiratory failure?
Imp of LPV! 24% ECMO group didn't get ECMO, 50% incomplete follow-up
- Population
- ARDS
- Intervention
- VV ECMO
- Control
- Not recorded
- Primary Outcome
- Not recorded
Does surgical decompression reduce case fatality and poor outcome in patients with space-occupying infarctions who are treated within 48h of stroke onset?
- Population
- Stroke
- Intervention
- Decompressive Craniectomy
- Control
- Standard Care
- Primary Outcome
- Survival with favourable neurology
Loading...
- Population
- Not recorded
- Intervention
- Not recorded
- Control
- Not recorded
- Primary Outcome
- Not recorded
In critically ill adults that are expected to be in Intensive Care for 3 days or more, does intensively controlled blood glucose compared to conventionally controlled blood glucose reduce mortality …
- Population
- Adult ICU Patients
- Intervention
- Intensive BSL control
- Control
- Conventional BSL control
- Primary Outcome
- 90 day mortality
In patients with an out-of-hospital cardiac arrest does removing the use of intravenous medications improve survival?
No improvement survival or neuro. Increase ROSC in PEA/asystole
- Population
- Cardiac Arrest
- Intervention
- Pre-hospital IV medications
- Control
- No IV Medication
- Primary Outcome
- Survival to hospital discharge