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PRORATA
2010 Antibiotics and Infection Sepsis
? ICUs
621 patients
Procalcitonin algorithm for guiding antibiotic therapy
Clinical Question
In adult patients with suspected bacterial infections, does
procalcitonin-guided antibiotic care compared to usual care reduce patient
exposure to antibiotics without increasing mortality?
Critical Appraisal
Critique
Non-inferiority margin of 10% for mortality. Mainly non-surgical patients.
- Population
- Adult ICU Patients
- Population Details
- Not recorded
- Intervention Arms
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Procalcitonin-based antibiotic care
PCT > 0.5 start antibiotics. PCT < 0.25 stop abx. PCT > 0.5 and increasing, change abx. - Control Arms
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Clinical decision
- Primary Outcome
- Days of antibiotic exposure
- Secondary Outcomes
- Less days of antibiotic exposure , No difference in LOS , No difference in ventilator free days
- P Value
- 0.01
Outcome Results
Not recorded