AN
NICE-SUGAR
2009 Nutrition
42 ICUs
6104 patients
Intensive insulin in the MICU/SICU
Clinical Question
In critically ill adults that are expected to be in Intensive Care for 3 days or more, does intensively controlled blood glucose compared to conventionally controlled blood glucose reduce mortality at 90 days?
Critical Appraisal
Critique
No effect on early mortality. Up to 10% treatment discontinuation.
- Population
- Adult ICU Patients
- Population Details
- Not recorded
- Intervention Arms
-
Intensive BSL control
BSL 4.5 to 6.0 mmol/L - Control Arms
-
Conventional BSL control
BSL < 10.0 mmol/L - Primary Outcome
- 90 day mortality
- Secondary Outcomes
- Severe hypoglycemia
- P Value
- 0.02
Outcome Results
Not recorded