FEAST
2011 Fluids
? ICUs
3141 patients
Fluid boluses (N/S, Alb or nil) in African children with severe infection
Clinical Question
In paediatric patients with severe febrile illnesses, in a resource limited
setting, do fluid boluses with albumin vs. saline vs. no fluid boluses
affect mortality?
Critical Appraisal
Key findings
Bolus fluids increase mortality at 28d, 90d (N/S & Alb) - NNH 30. Poor external validity, rural setting with limited resources, mostly children with malaria.
Critique
Poor external validity.
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
Albumin or saline bolus, 20-40ml/kg
Albumin or saline bolus, 20-40ml/kg - Control Arms
-
No bolus
- Primary Outcome
- Not recorded
- Secondary Outcomes
- Increase in mortality , Increased pulmonary oedema
- P Value
- Not recorded
Outcome Results
Not recorded
Primary location: Uganda
Landmark trial