HAMLET
2009 Neurology
? ICUs
64 patients
Clinical Question
Does surgical decompression reduce case fatality and poor outcome in patients with space-occupying infarctions who are treated within 48h of stroke onset?
Critical Appraisal
Critique
Results combined with DESTINY and DECIMAL
- Population
- Stroke
- Population Details
- malignant MCA infarction
- Intervention Arms
-
Decompressive Craniectomy
decompressive craniectomy - Control Arms
-
Standard Care
- Primary Outcome
- Survival with favourable neurology
- Secondary Outcomes
- A 50% reduction in mortality
- P Value
- 0.05
Outcome Results
Not recorded
Primary location: Netherlands
Landmark trial