Determann
2010 Respiratory
2 ICUs
150 patients
Non-ARDS: high (10ml/kg) vs low (6ml/kg) Vt ventilation (cytokine levels)
Clinical Question
In mechanically ventilated patients without acute lung injury or acute respiratory distress (ALI/ARDS), does lower tidal volume ventilation at 6 ml/kg (Vt-low), compared to conventional tidal volume ventilation at 10 ml/kg (Vt-high), reduce cytokine levels associated with lung injury?
Critical Appraisal
Key findings
Low Vt > dec plasma IL-6. No diff BAL cytokine levels. Stopped early (more ALI in hi Vt)
- Population
- Adult ICU Patients
- Population Details
- Not recorded
- Intervention Arms
-
Low volumes
6 ml/kg - Control Arms
-
High volumes
10 ml/kg - Primary Outcome
- Not recorded
- Secondary Outcomes
- Not recorded
- P Value
- Not recorded
Outcome Results
Not recorded
Primary location: Netherlands