Randomized Controlled Trials

In patients with necrotising soft tissue infection (NSTI), does the use of intravenous immunoglobulin (IVIG) compared to placebo improve patient reported physical outcomes?

No sig diff.Mult issues (imbal orgms, HBOT, low dose IVIg, 1 dose pre enrol ok)

In adult patients who have sepsis, does levosimendan reduce the incidence and severity of acute organ dysfunction compared with placebo?

No difference in SOFA (organ failures & mortality) but increased duration of MV, SVTs

In patients with in-hospital cardiac arrest, does Shenfu (a traditional Chinese medicine), improve 28 day mortality?

In critically ill patients, with mild renal failure, does furosemide infusion compared to placebo worsen kidney function?

In adult patients post out of hospital cardiac arrest, does a continuous or on demand application of neuromuscular blockade (NMB) reduce the number of shivering episodes during targeted temperature management …

In critically ill patients requiring transfusion, does the transfusion of the freshest available red cells compared to standard care impact on patient mortality?

Sub-group analysis: Patients with higher risk of death (APACHE III) - 90 day mortality significantly greater in the short-term storage group

In cancer patients with septic shock does a restrictive vs. a liberal transfusion threshold reduce 28 day mortality?

Trend towards benefit in liberal grp but mult issues (sml no PRBC, 41%v61% transfused)

In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial …

In adults with out of hospital cardiac arrest (OOHCA) due to a presumed cardiac cause, who are post ‘return of spontaneous circulation’ (ROSC), does cooling to 33°C for 48 hours, …

Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?

Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects.

In patients aged 80 years or older, with unstable angina/non-ST elevation myocardial infaction (NSTEMI), does an early invasive strategy compared with a conservative strategy, reduce the composite outcome of myocardial …

In critically ill patients with acute kidney injury does early compared with delayed initiation of renal replacement therapy (RRT) improve mortality at 60 days?

No change mortality, ~50% late group no RRT, sig more CRBSI in early grp

In adult patients with nontraumatic out-of-hospital cardiac arrest and shock-refractory ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT), does amiodarone or lidocaine along with standard care result in improved survival …

No sig o/c diff. Subgroup benefit A & L (witnessed arrest). Amoid > more pacing

In patients with acute ischaemic stroke, is low-dose thrombolysis therapy with intravenous alteplase non-inferior to standard-dose therapy with respect to death and disability at 90 days?

In patients with acute intracerebral haemorrhage and who are hypertensive, does rapid lowering of systolic blood pressure compared to standard therapy improve patient outcomes ?

Don't support early aggressive lower BP. iv nicardipine>iv labetalol

In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?

No Mort diff.Cont inf-superior PK/PD, clin cure rate, wcc norm, vent free days

In ICU patients with septic shock who have had initial fluid resuscitation, what are the effects and feasibility of a protocol restricting further resuscitation fluid as opposed to standard care?

Less resus fluid feasible, no diff total fluid. Limit post resus fluid to dyn fluid resp indices

Is Dexmedetomidone effective in reducing the incidence of agitated delirium and days on a ventilator?

Dec time to extubation, more rapid resolution delirium & sedation/analgesia sparing

Does acetazolamide reduce the duration of mechanical ventilation in critically ill patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis?

No stat sig reduction in duration MV

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Too many study flaws to confirm reduced Ad/Nad/O2ER with Met Blue

In adult patients on ICU, does early initiation of RRT compared to delayed initiation of RRT reduce mortality at 90 days?

Sig reduction 90d mortality & renal recovery, RRT duration, duration MV, hosp LOS

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No sig diff in pts alive & free of inv fungal infect at 28d. Red inv fung infections. Well tol

#N/A

In critically ill adult patients receiving parenteral nutrition, does high amino acid intake compared with standard level amino acid intake, result in greater hand grip strength at ICU discharge?

No diff in hand strength at D/C. Only small diff in AA delivery. Also E diff. Minor diff 2 o/c

#N/A