TRANSFUSE
2017 Transfusion
? ICUs
4994 patients
Clinical Question
In critically ill patients requiring transfusion, does the transfusion of the freshest available red cells compared to standard care impact on patient mortality?
Critical Appraisal
Key findings
Sub-group analysis:
Patients with higher risk of death (APACHE III) -
90 day mortality significantly greater in the short-term storage group
Critique
The finding of higher mortality in the sicker patient group is of unknown significance
- Population
- Adult ICU Patients
- Population Details
- Requiring RBCs
- Intervention Arms
-
RBCs
Transfusion of the freshest available blood ~12 days old - Control Arms
-
Transfusion of the oldest available compatible blood ~22d
- Primary Outcome
- 90 day mortality
- Secondary Outcomes
- More febrile reactions , No difference in serious adverse events , No difference in LOS
- P Value
- 0.46
Outcome Results
Not recorded
Primary location: Worldwide
ANZICS
Landmark trial