WOMAN

2017 Haemostasis

? ICUs

20060 patients

Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?

Clinical Question

Does the early administration of tranexamic acid (TXA), compared with
placebo, reduce death from bleeding in women with post-partum haemorrhage
(PPH)?

Critical Appraisal

Key findings

Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects.

Critique

Design changes AFTER the study was commenced. No screening for VTE.

Population: Postpartum Haemorrhage
Population Details: Not recorded
Intervention Arms: 1g TXA over 10 minutes
1g TXA over 10 minutes
Control Arms: Placebo
Primary Outcome: Composite mortality or hysterectomy
Secondary Outcomes: Less bleeding related deaths
P Value: 0.65

Outcome Results

Not recorded

Primary location: Worldwide Landmark trial