LeoPARDS
2017 Sepsis
? ICUs
516 patients
Levosimendan in sepsis - incidence & severity of organ dysfunction. Septic shock (<24h) on vasopressors (>4h). Levo (0.05-0.2ug/kg/min) vs placebo for 24h No ECHO!
Clinical Question
In adult patients who have sepsis, does levosimendan reduce the incidence
and severity of acute organ dysfunction compared with placebo?
Critical Appraisal
Key findings
No difference in SOFA (organ failures & mortality) but increased duration of MV, SVTs
Critique
No echocardiographic analysis was performed
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
Levosimendan (0.05-0.2ug/kg/min) for 24 hours plus standard of care
Levosimendan (0.05-0.2ug/kg/min) for 24 hours plus standard of care - Control Arms
-
Placebo
- Primary Outcome
- Not recorded
- Secondary Outcomes
- Low likelihood of successful wean from mechanical ventilation , Increased rate of SVT , No difference in mortality
- P Value
- Not recorded
Outcome Results
Not recorded
Primary location: UK
Landmark trial