ICU EBM
Evidence Library
In patients with wide QRS (probably ventricular) tachycardia, does intravenous procainamide compared with intravenous amiodarone reduce major adverse cardiac events?
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Does a modified Valsalva technique, incorporating a leg lift procedure, result in improved success in converting a supraventricular tachycardia to sinus rhythm in patients presenting to the Emergency Department?
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Does the application of cricoid pressure during induction of anaesthesia control the regurgitation and pulmonary aspiration of gastric or oesophageal contents?
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In patients with suspected acute coronary syndrome does a rapid diagnostic pathway allow early discharge from hospital without more adverse effects when compared with a conventional diagnostic assessment and discharge …
In patients with severe community-acquired pneumonia and high inflammatory response, does the use of corticosteroids compared to placebo improve outcom
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In hospitalised patients with community-acquired pneumonia (CAP), is five days of antibiotic therapy non-inferior to standard practice with respect to clinical improvement?
In paediatric patients with septic shock, does adrenaline compared with dopamine reduce 28 day mortality?
Does early rehabilitation reduce physical impairment and ICU length of stay in critically ill patients?
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To evaluate the prevalence of VExUS grades and their association with Major Adverse Kidney Events (MAKE-30) and mortality in critically ill patients.
In adult intensive care patients does the use of a balanced crystalloid compared to 0.9% saline reduce 90-day all-cause mortality? In adult intensive care patients needing administration of resuscitation fluids, …
Primary outcome: No significant difference in 90-day mortality 1381 of 5230 patients (26.4%) assigned to a balanced solution died vs 1439 of 5290 patients (27.2%) assigned to saline solution (adjusted HR, 0.97 [95% CI, 0.90-1.05]; …
In patients with or at risk of Acute Respiratory Distress Syndrome (ARDS), can nebulised heparin compared to placebo, accelerate recovery of physical function?
Primary outcome: SF-36 Physical Function Score (patient or proxy reported limitations across ten physical activities) of survivors at day 60 – no significant differenceIntervention group vs control group: (95% CI): 53.6 vs 48.7, MD 4.9 …
In patients with moderate-severe ARDS, does dexamethasone in addition to routine care, compared with routine care alone increase ventilator free days up to day 28?
Primary outcome: Number of ventilator free days – significantly greater in the dexamethasone group 12.3 (SD 9.9) vs 7.5 (SD 9.0)Difference 4.8 days (95% CI 2.57-7.03), p<0.0001
In patients with cardiogenic shock, does milrinone as compared with dobutamine improve the composite outcome of in-hospital death, resuscitated cardiac arrest, receipt of cardiac transplant or mechanical circulatory support, non-fatal …
Primary outcome: no significant difference in the composite of in-hospital death, resuscitated cardiac arrest, receipt of cardiac transplant or mechanical support, non-fatal myocardial infarcation, cerebrovascular event or renal replacement therapy. Comparing milrinone vs dobutamine group …
In adult trauma patients with major haemorrhage and hypofibrinogenaemia does the use fibrinogen concentrate (FC) compared to cryoprecipitate (cryo) result in a shorter time to administration?
Primary outcome: Median times for commencement of FC vs. cryo following hospital admission – significantly reduced in FC group29 (23-40) minutes vs. 60 (40 – 80 minutes)Log rank test for equality of time to event, …
