FEISTY
2021 HaemostasisFibrinogen Early In Severe Trauma studY (FEISTY): results from an Australian multicentre randomised controlled pilot trial
Clinical Question
In adult trauma patients with major haemorrhage and hypofibrinogenaemia
does the use fibrinogen concentrate (FC) compared to cryoprecipitate (cryo)
result in a shorter time to administration?
Critical Appraisal
Key findings
Primary outcome: Median times for commencement of FC vs. cryo following hospital admission –
significantly reduced in FC group29 (23-40) minutes vs. 60 (40 – 80 minutes)Log rank test for equality of time to event, p = 0.0001
Critique
In severely injured, hypofibrinogenaemic patients the administration of FC
may be achieved faster than transfusion of cryoprecipitate
- Population
- Trauma Patients
- Population Details
- significant haemorrhage
- Intervention Arms
-
Fibrinogen concentrate
- Control Arms
-
Cryoprecipitate
- Primary Outcome
- Not recorded
- Secondary Outcomes
- Not recorded
- P Value
- 0.0001
Outcome Results
Not recorded
Primary location: Australia