Evidence Library

Randomized Controlled Trials

Pandharipande

2006 Sedation and Delirium

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Pontes-Arruda

2006 Nutrition

103

#N/A

Dec mortality, ICU-free days, vent free days + improve P/F d4&7 + new organ failures

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Positive fluid balance strongly a/w ICU mortality. Worse o/c with ICU acquired sepsis. Odds Ratio for mortality ↑ by 1.1 for every 1000 ml positive fluid balance. Sicker and older patients received more fluid.

Population: Sepsis
Intervention: Positive fluid balance
Control: Standard Care
Primary Outcome: Not recorded

COMMIT

2005 Cardiology

Question not recorded

Population: AMI
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

ESCAPE

2005 Haemodynamics

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

ISAT

2005 Neurology

2143

Question not recorded

Coil-dec mort (to 7yrs), slight inc rebleed. Clip-more seizures post-op

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Mayer 2005

2005 Haemostasis

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Nava

2005 Respiratory

Question not recorded

NIV > reduced need for reintubation (& reintubation indep a/w inc ICU mortality)

Population: Adult ICU Patients
Intervention: NIV
Control: Not recorded
Primary Outcome: Re-intubation within 72 hours

PAC-Man

2005 Haemodynamics

Pulmonary Artery Catheters in patient Management PAC-MAN study group, Lancet 2005;366;472-477 Clinical Question In critically ill patients, does the use of a pulmonary artery catheter (PAC) reduce mortality? Design Randomised …

Population: Adult ICU Patients
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Bouderka

2004 Airway Trauma

Does early tracheostomy reduce duration of mechanical ventilation and mortality in comparison with prolonged intubation in patients with head injury?

No diff mort. Multiple issues with study - reports benefit, but no

Population: Traumatic Brain Injury
Intervention: Early tracheostomy (Day 5/6)
Control: Prolonged endotracheal intubation
Primary Outcome: Mechanical ventilation days

CRASH-1

2004 Neurology

10008

In adults with a head injury, do early corticosteroids compared to placebo reduce death and disability?

Don't give steroids routinely in TBI (study stopped early)

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Esteban

2004 Respiratory

221

Inc mort in NIV (? Due to delay reintubation) - same reintubation rate both grps. NNH = 9

Population: Adult ICU Patients
Intervention: NIV
Control: Not recorded
Primary Outcome: Not recorded

SAFE

2004 Fluids

6997

Does fluid resuscitation with albumin, compared to saline, affect mortality for patients in the ICU?

No mortality difference. Alb:N/S=1:1.4L. Alb safe. Post-hoc Alb worse TBI

Population: Adult ICU Patients
Intervention: 4% Albumin
Control: Normal Saline
Primary Outcome: Not recorded

Chastre 2003

2003 Antibiotics and Infection

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Bernard

2002 Cardiac Arrest

33C for 12 hours in patients with VF OHCA vs no temperature management improved survival with good neuro function.

Population: Cardiac Arrest
Intervention: 33°C for 12h within 2h of ROSC
Control: No temperature management
Primary Outcome: Survival with good neurology

de Gans 2002

2002 Steroids

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

MAPPET-3

2002 Anticoagulation

256

#N/A

Reduced need for rescue thrombolysis. No mortality benefit. Stopped early

Population: Pulmonary Embolism
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Leuven I

2001 Nutrition

#N/A

Population: Not recorded
Intervention: Insulin
Control: Not recorded
Primary Outcome: Not recorded

PROWESS

2001 Sepsis

1690

In patients with septic shock, does Activated Protein C (also known as drotrecogin alfa or DrotAA) compared with placebo reduce mortality?

Recombinant APC > RRR 19%, ARR 6% - NNT 16. Non-sig inc in serious bleeding NNH 67

Population: Sepsis
Intervention: Activated Protein C
Control: Placebo
Primary Outcome: 28 day mortality

Rivers

2001 Sepsis

263

Question not recorded

EGDT > dec hosp (NNT 6), 28d & 60d mort. Improved ScvO2, lact clearance, MAP

Population: Sepsis
Intervention: EGDT
Control: Standard Care
Primary Outcome: Not recorded

ANZICS Dopamine

2000 Renal

328

In patients renal dysfunction, does dopamine reduce the severity of acute kidney injury?

Low dose dopamine > no clin sig degree of renal protection

Population: Not recorded
Intervention: Dopamine
Control: Placebo
Primary Outcome: creatinine concentration

ARDSnet

2000 Respiratory

861

In patients with Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS), does ventilation with lower tidal volumes compared with traditional higher tidal volumes reduce death or ventilator-free days?

Low Vt > dec mortality, increased vent free days

Population: ARDS
Intervention: Low volumes
Control: High volumes
Primary Outcome: All-cause mortality

HACA

2000 Cardiac Arrest

275

In adults who suffer cardiac arrest due to ventricular fibrillation, does mild hypothermia compared with standard normothermia improve neurological outcome at 6 months?

Improved mortality & neuro (6m) with 32-34 deg, only 8% screened included

Population: Cardiac Arrest
Intervention: 32–34°C for 24h
Control: No temperature management
Primary Outcome: Neurological Outcome

Kress

2000 Sedation and Delirium

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded

Lau

2000 Acid Suppression

#N/A

Population: Not recorded
Intervention: Not recorded
Control: Not recorded
Primary Outcome: Not recorded