ARDSnet
2000 Respiratory
2 ICUs
861 patients
Lower tidal volumes for ARDS: 6ml/kg + Pplat < 30 vs 12ml/kg + Pplat < 50cmH2O
Clinical Question
In patients with Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS), does ventilation with lower tidal volumes compared with traditional higher tidal volumes reduce death or ventilator-free days?
Critical Appraisal
Key findings
Low Vt > dec mortality, increased vent free days
Critique
High volumes in control group.
- Population
- ARDS
- Population Details
- PaO2/FiO2 < 300mmHg
- Intervention Arms
-
Low volumes
6ml/kg - Control Arms
-
High volumes
12ml/kg - Primary Outcome
- All-cause mortality
- Secondary Outcomes
- Less mechanically ventilated days
- P Value
- 0.01
Outcome Results
Not recorded
Primary location: USA
Landmark trial