?
DESTINY
2007 Neurology
? ICUs
32 patients
Clinical Question
Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction
Critical Appraisal
Critique
DESTINY showed that hemicraniectomy reduces mortality in large hemispheric stroke. With 32 patients included, the primary end point failed to demonstrate statistical superiority of hemicraniectomy, and the projected sample size was calculated to 188 patients. Despite this failure to meet the primary end point, the steering committee decided to terminate the trial in light of the results of the joint analysis of the 3 European hemicraniectomy trials.
- Population
- Stroke
- Population Details
- malignant MCA infarction
- Intervention Arms
-
Decompressive Craniectomy
decompressive craniectomy - Control Arms
-
Standard Care
- Primary Outcome
- Survival with favourable neurology
- Secondary Outcomes
- A 50% reduction in mortality
- P Value
- 0.9
Outcome Results
Not recorded