CRASH-3
2019 Neurology Trauma
175 ICUs
12737 patients
Clinical Question
In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce…
Critical Appraisal
Critique
Differences between clinicians may exist as to what constituted a TBI associated death
- Population
- Traumatic Brain Injury
- Population Details
- within 3 hrs of injury
- Intervention Arms
-
TXA (n=6406)
TXA 1g over 10 mins, then 1g over 8 hours - Control Arms
-
Placebo (n=6331)
- Primary Outcome
- 28 day mortality
- Secondary Outcomes
- No difference in VTE
- P Value
- 0.07
Outcome Results
28 day mortality
Primary · Dichotomous (events / total)| Role | Arm | Result |
|---|---|---|
| I | TXA | 855 / 4613 (18.5%) |
| C | Placebo | 892 / 4514 (19.8%) |
TXA vs Placebo: RR 0.94 (95% CI 0.86–1.02) · risk difference -1.2 percentage points
Primary location: Worldwide
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