?
CORTICUS
2008 Sepsis Steroids
? ICUs
499 patients
Hydrocortisone therapy for septic shock
Clinical Question
In adult patients with severe septic shock, does hydrocortisone versus
placebo reduce mortality at 28 days?
Critical Appraisal
Key findings
No difference in mortality. This deviates from the results of Annane 2002. Hastened reversal of shock.
Critique
Failed to recruit required numbers. Mortality a lot lower than estimate.
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
Hydrocortisone 50 mg QID for 5 days
Hydrocortisone 50 mg QID for 5 days - Control Arms
-
Placebo
- Primary Outcome
- Not recorded
- Secondary Outcomes
- No difference in mortality , Hastened the reversal of shock , Increase rate of superinfection
- P Value
- Not recorded
Outcome Results
Not recorded