CITRI-ALI
2019 Sepsis
? ICUs
170 patients
Clinical Question
In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury?
Critical Appraisal
Critique
46 prespecified secondary outcomes
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
Vitamin C
50mg/kg vitamin C q6h - Control Arms
-
Placebo
- Primary Outcome
- composite SOFA score, CRP and thrombomodulin
- Secondary Outcomes
- improved 28 day mortality and ICU free days
- P Value
- 0.86
Outcome Results
Not recorded
Primary location: USA
Landmark trial