HOT-ICU
2021 RespiratoryLower or Higher Oxygen Targets for Acute Hypoxaemic Respiratory Failure
Clinical Question
In patients with acute hypoxaemic respiratory failure, does a lower vs higher oxygenation target reduce mortality at 90 days?
Critical Appraisal
Key findings
Primary outcome: 90-day all–cause mortality – no significant difference42.9% vs 42.4% (Risk ratio 1.02, 95% C.I. 0.94-1.11, p = 0.64)
- Population
- ARDS
- Population Details
- Not recorded
- Intervention Arms
-
Low oxygen target (n=1441)
- Control Arms
-
High oxygen target (n=1447)
- Primary Outcome
- 90 day mortality
- Secondary Outcomes
- Not recorded
- P Value
- Not recorded
Outcome Results
90 day mortality
Primary · Dichotomous (events / total)| Role | Arm | Result |
|---|---|---|
| I | Low oxygen target | 618 / 1441 (42.9%) |
| C | High oxygen target | 613 / 1447 (42.4%) |
Low oxygen target vs High oxygen target: RR 1.01 (95% CI 0.93–1.10) · risk difference 0.5 percentage points
Primary location: Denmark