REALITY

Clinical Question

In patients with acute myocardial infarction and anaemia is a restrictive,
compared with a liberal transfusion strategy, non-inferior with respect to
major adverse cardiovascular outcomes at 30 days?

Critical Appraisal

Key findings

Primary outcome: 30 day MACE (a composite score of major adverse cardiovascular events –
all-cause death, stroke, recurrent MI, emergency revascularisation prompted
by ischaemia) At day 30, MACE had occurred in 14% in liberal group and 11% in restrictive
group (45 vs 36 patients, between group difference -3% 95% CI -8.4% to
2.4%). This met the pre-specified non-inferiority criterionPrimary outcome analysis was of the as-treated populationAs-randomised population had very similar results

Critique

In patients with AMI and anaemia, a restrictive transfusion strategy
compared with a liberal transfusion strategy was non-inferior in regards to
30 day MACE outcomes

Outcome Results

Not recorded