TTM2

2021 Cardiac Arrest

61 ICUs

1861 patients

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

Clinical Question

In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?

Critical Appraisal

Key findings

No difference in all-cause mortality at 6 months Comparing HYPOTHERMIA vs NORMOTHERMIA 50% (465/925) vs 48% (446/925) RR 1.04 (95% CI 0.94-1.14, p = 0.37) HR for death in hypothermia group 1.08 (95% CI 0.95-1.23)

Critique

In patients suffering out-of-hospital cardiac arrest, induced hypothermia did not lead to lower mortality. Functional outcome and health related quality of life did not improve from hypothermia

Population: Cardiac Arrest
Population Details: Not recorded
Intervention Arms: TTM at 33C
Control Arms: Normothermia
Primary Outcome: 6 month mortality
Secondary Outcomes: No difference in any secondary outcome
P Value: 0.37

Outcome Results

Not recorded

Primary location: Worldwide Landmark trial