VASST
2008 Haemodynamics Sepsis
27 ICUs
778 patients
Vasopressin vs additional NAd for septic shock
Clinical Question
In adult patients with septic shock, does the addition of vasopressin
infusion to a norepinephrine infusion compared to a norepinephrine infusion
alone decrease mortality rate at 28 days?
Critical Appraisal
Key findings
No benefits but was underpowered for observed mortality rate. No increase adverse effects. Low vasopressin dose, high baseline MAP suggesting no refractory shock, internal validity issues due to post-randomisation exclusion.
Strengths
Multi-centre trial
Critique
Vasopressin dose was low. Exclusion of patients post-randomisation.
- Population
- Sepsis
- Population Details
- Septic shock
- Intervention Arms
-
Vasopressin
0.01-0.03 U/min - Control Arms
-
Noradrenaline
5 to 15 microg per minute - Primary Outcome
- 28 day mortality
- Secondary Outcomes
- No difference in mortality , No difference in serious adverse events , Less use of noradrenaline
- P Value
- 0.26
Outcome Results
Not recorded
Primary location: Canada
Other locations: Canada
Landmark trial