TTM
2013 Cardiac Arrest Cardiology
? ICUs
950 patients
OOHCA: 33 vs 36 degrees- 28hrs at Temp, warm 0.5/hr, apyrexia 72hrs post RND
Clinical Question
In adults that suffer an out-of-hospitals (OOH) cardiac arrest of presumed
cardiac cause, does induced therapeutic hypothermia targeting 36°C compared
to 33°C reduce mortality or reduce neurological deficit?
Critical Appraisal
Key findings
No diff mortality (all cause) or neuro (mRS, CPC). Not gen to long downtime
Critique
Not generalisable to arrests with long or unknown downtime.
- Population
- Cardiac Arrest
- Population Details
- GCS < 8, Out of Hospital Cardiac Arrest, Presumed cardiac cause
- Intervention Arms
-
36°C compared to 33°C
28 hours targeting 36°C, rewarmed 0.5°C per hour - Control Arms
-
Target temp 33°C
- Primary Outcome
- All-cause mortality
- Secondary Outcomes
- No difference in mortality , No difference in neurological outcome
- P Value
- 0.51
Outcome Results
Not recorded
Primary location: Europe
Landmark trial