TOPCOAT
2014 Anticoagulation
8 ICUs
83 patients
Submassive PE: heparin +/- tenecteplase
Clinical Question
In patients with submassive PE, does the use of tenecteplase + heparin,
compared to heparin alone, improve patient orientated outcomes?
Critical Appraisal
Key findings
Nil sig. Complex composite primary outcome (PE or treatment related, 5d, w/i 90d)
- Population
- Pulmonary Embolism
- Population Details
- Submassive PE
- Intervention Arms
-
Tenecteplase
- Control Arms
-
Placebo
- Primary Outcome
- Composite
- Secondary Outcomes
- Not recorded
- P Value
- Not recorded
Outcome Results
Not recorded
Primary location: USA
Landmark trial