TARGET
2019 Nutrition
46 ICUs
3914 patients
1 vs 1.5kcal/ml EN for upto 28d in MV pts > 90d mortality, 180d function
Clinical Question
In mechanically ventilated, critically ill patients receiving enteral
nutrition does energy-dense feed (1.5kCal/ml) compared with routine feed
(1kCal/ml) impact on 90 day all cause mortality?
Critical Appraisal
Critique
Only 2% of patients were malnourished, and the trial conducted only in ANZ - poor extrapolation to other ICUs.
- Population
- Adult ICU Patients
- Population Details
- Not recorded
- Intervention Arms
-
Energy dense feed
Target rate of 1ml/kg of 1.5 kcal/ml (~1900kcal/day) - Control Arms
-
Standard feed
Target rate of 1ml/kg of 1kcal/ml (~1300kcal/day) - Primary Outcome
- 90 day mortality
- Secondary Outcomes
- No difference in mortality , More vomiting , No difference in any secondary outcome
- P Value
- 0.41
Outcome Results
Not recorded
Primary location: Australia
ANZICS
Landmark trial