?
ARISE
2014 Sepsis
? ICUs
1600 patients
EGDT vs usual care in early septic shock (w/i 6hrs & for 6hrs - ScvO2). <2L fluid in 1st 6hrs
Clinical Question
In adult patients with septic shock, does early goal-directed therapy
(EGDT) compared with standard therapy reduce mortality at 90 days?
Critical Appraisal
Key findings
No 28d or 90d mortality benefit, MV dur, ICU LOS, RRT. Usual care > less ICU, rbc, CVC
Critique
Lower APACHE scores than ProCESS and Rivers
- Population
- Sepsis
- Population Details
- Septic shock
- Intervention Arms
-
EGDT
6h of EGDT based on Rivers' trial - Control Arms
-
Standard Care
- Primary Outcome
- 90 day mortality
- Secondary Outcomes
- No difference in mortality
- P Value
- 0.9
Outcome Results
Not recorded