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SEPSISPAM
2014 Haemodynamics Sepsis
? ICUs
776 patients
High versus low MAP goal in septic shock
Clinical Question
In patients with septic shock does a high target mean arterial pressure
(MAP), compared to a low target MAP, improve mortality?
Critical Appraisal
Key findings
No mortality difference but the subgroup with chronic hypertension had lower rates of AKI and dialysis. Underpowered because of lower than predicted mortality. Limited external validity due to use of steroids and protein C
Strengths
Randomised
Critique
Underpowered. Limited external validity.
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
Target MAP 80-85
Target MAP 80-85 - Control Arms
-
target MAP 65-70
- Primary Outcome
- 28 day mortality
- Secondary Outcomes
- No difference in mortality , No difference in serious adverse events , Increased rate of new AF , Subgroup - patients with chronic HTN had significantly lower rate of AKI
- P Value
- 0.57
Outcome Results
Not recorded