ProMISe
2015 Sepsis
? ICUs
1260 patients
EGDT vs usual care in early septic shock - same incl as ARISE (Abx before RND)
Clinical Question
In adult patients with septic shock, does early goal-directed therapy
(EGDT) compared with standard therapy reduce mortality at 90 days?
Critical Appraisal
Key findings
No diff in 90d mort. EGDT not cost effective
Critique
Non - blinded. Only 1/3 of eligible patients recruited.
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
EGDT
EGDT for 6h. CVP > 8, MAP > 65, ScvO2 > 70% - Control Arms
-
Standard Care
- Primary Outcome
- 90 day mortality
- Secondary Outcomes
- Not recorded
- P Value
- 0.9
Outcome Results
Not recorded
Primary location: UK
Landmark trial