ProCESS
2014 Sepsis
? ICUs
1341 patients
EGDT vs Protocol (Hb > 75, discourage CVP, SCVO2) vs no protocol for Early Septic Shock
Clinical Question
In adult patients with sepsis, does protocol-based care compared to usual
care reduce death within 60 days?
Critical Appraisal
Key findings
No diff 60d mort, LOS, A/Es. More new RRT in in std Rx. No CVC, dobutamine, Hb<75 ok
Critique
Changed inclusion criteria during trial. Power calculation based on a high mortality.
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
EGDT vs protocol based care
EGDT vs protocol-based vs standard of care - Control Arms
-
Standard Care
- Primary Outcome
- 60 day mortality
- Secondary Outcomes
- No difference in any secondary outcome
- P Value
- 0.89
Outcome Results
Not recorded
Primary location: USA
Landmark trial