PHARLAP
2019 Respiratory
? ICUs
113 patients
Clinical Question
Does an open lung ventilation strategy which includes maximal recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) titration improve outcomes compared to traditional lung-protective ventilation in patients with moderate – severe acute respiratory distress syndrome (ARDS)?
Critical Appraisal
Critique
Stopped early due to results of the ART trial
- Population
- ARDS
- Population Details
- Severe ARDS
- Intervention Arms
-
Open lung ventilation with recruitment maneuvres
Staircase RMs - 20 -> 30 -> 40 cmH2O. Stepwise PEEP titration, min 15 cmH2O - Control Arms
-
Recruitment manoeuvres not permitted
- Primary Outcome
- Ventilator free days at day 28
- Secondary Outcomes
- No difference in mortality , No difference in any secondary outcome
- P Value
- 0.95
Outcome Results
Not recorded
Primary location: Worldwide
ANZICS
Landmark trial