PEPTIC
2020 Acid Suppression
? ICUs
26771 patients
Clinical Question
In ICU patients requiring invasive mechanical ventilation, does the use of proton pump inhibitors (PPIs) vs. histamine-2 receptor blockers (H2RBs) for stress-ulcer prophylaxis, reduce 90-day mortality?
Critical Appraisal
Key findings
Post-Hoc Analysis:
Difference in mortality was mostly found in the group of patients with high illness severity
Critique
There was a large proportion of crossover from the intervention arm to the control arm
- Population
- Adult ICU Patients
- Population Details
- ICU patients requiring invasive mechanical ventilation
- Intervention Arms
-
PPI
Proton pump inhibitor - Control Arms
-
Histamine-2 Receptor Blocker
- Primary Outcome
- 90 day mortality
- Secondary Outcomes
- Less upper GI bleeding , No difference in C. diff infections
- P Value
- 0.9
Outcome Results
Not recorded
Primary location: Worldwide
ANZICS
Landmark trial