MOPETT
2013 Anticoagulation
1 ICUs
121 patients
Alteplase for moderate PE: anticoagulation +/- thrombolsis effect on PA press
Clinical Question
In patients with moderate Pulmonary Embolism (PE), does low dose thrombolysis + anticoagulation, compared with anticoagulation alone, reduce pulmonary artery pressure at 28 months?
Critical Appraisal
Key findings
Safe. Reduced PASP at 28 months. Old (anatomical) definitions PHT. No mort power
Critique
Single centre, Patients and clinicians non-blinded
- Population
- Pulmonary Embolism
- Population Details
- Submassive PE
- Intervention Arms
-
tPA
10mg bolus, followed by 40mg within 2 hours (half standard dose) - Control Arms
-
Control
- Primary Outcome
- pulmonary artery pressure at 28 months
- Secondary Outcomes
- No difference in bleeding
- P Value
- 0.01
Outcome Results
Not recorded
Primary location: USA
Landmark trial