?
ALBIOS
2014 Fluids
? ICUs
1818 patients
Daily 20% Alb for Alb > 30g/L in severe sepsis (SIRS + infection + >1 SOFA organ failure)
Clinical Question
In adults with severe sepsis or septic shock, does 20% albumin solution
with crystalloid fluid compared to crystalloid fluid alone reduce death
with 28 days?
Critical Appraisal
Key findings
No benefit. Maintenance, not resus. Alb > more PRBCs
Critique
Under powered. Open label - poor internal validity
- Population
- Sepsis
- Population Details
- Not recorded
- Intervention Arms
-
20% albumin on top of crystalloid
20% albumin on top of crystalloid - Control Arms
-
Crystalloid
- Primary Outcome
- 28 day mortality
- Secondary Outcomes
- No difference in mortality , No difference in serious adverse events
- P Value
- Not recorded
Outcome Results
Not recorded